Guillermo Maripán joined Universidad Católica when he was nine years old and won the Apertura and Clausura championships in Chile in 2016 with the club. In the summer of 2017, he joined La Liga club Alavés in Spain. In the last two seasons, the central defender played 47 matches for the Spanish club. A semi-finalist in the Copa America 2019, the native of Vitacura joined AS Monaco on August 24, 2019 for five seasons.